Set in a retro-futuristic version of Southern California after a nuclear disaster, the show follows Lucy (Ella Purnell), a young woman who emerges from Vault 33 in search of her kidnapped father, Hank (Kyle MacLachlan). Navigating a wasteland filled with mutants, bandits, and moral ambiguity, Lucy confronts the harsh realities of a fractured society. The series blends dark humor, political satire, and survival drama, capturing the essence of the beloved video game franchise while introducing new characters and stories.